Contraindicated (one)pentobarbital will decrease the extent or effect of roflumilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the extent or influence of isavuconazonium sulfate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.Contraindicated (one)pentobarbital will lessen the level